Publications from our lab

PI publication name: Sara S. Nunes
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Mourad O, Mastikhina O, Khan S, Hatkar R, Williams K and Nunes SS (corresponding author). “Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip”. ACS Mater. Au (2023)
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Mourad O, Yee R, Li M and Nunes SS (corresponding author). “Modeling Heart Diseases on a Chip: Advantages and Future Opportunities” Circulation Research. (2023)
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Khan S, Ahuja N, Vorha S, Cleaver O and Nunes SS (corresponding author). “Uncovering the transcriptomic heterogeneity of pancreatic endothelial cells using integrative and comparative single cell gene expression analysis”. BioRxiv (2023)
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Sun X, Aghazadeh Y and Nunes SS (corresponding author). “Isolation of ready-made rat microvessels and its application in effective in vivo vascularization and in angiogenic studies in vitro“ Nature Protocols. (2022)
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Soon K, Li M, Wu R, Zhou A, Khosraviani N, Turner WD, Wythe J, Fish JE and Nunes SS (corresponding author). “A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks” Biomaterials. (2022)
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Loai S, Sun S, Husain M, Laflamme MA, Yeger H, Nunes SS, Cheg HL. “Microvascular dysfunction in skeletal muscle precedes myocardial vascular changes in diabetic cardiomyopathy: sex-dependent differences” Frontiers in Cardiovascular Medicine, 1291 (2022).
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Aghazadeh Y, Sarangi F, Poon F, Nkennor B, Nunes SS, Nostro MC. “GP2+ pancreatic progenitors generate functional beta cells and do not form teratoma in vivo”. Stem Cell Reports (2022).
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Soon K, Wu R, Turner WD, Wythe JD, Fish J and Nunes SS (corresponding author). “Development and characterization of a human model of arterio-venous malformations-on-a-chip”. bioRxiv. (2022).
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Tracy EP, Stielberg V, Rowe G, Benson D, Nunes SS, Hoying JB, Murfee WL, LeBlanc AJ. “State of the Field: Cellular Therapy Approaches in Microvascular Regeneration”. APJ-Heart and Circulatory Physiology. (2022) In press. (DOI: 10.1152/ajpheart.00674.2021)
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Aghazadeh Y, Sarangi F, Poon F, Wong F, Khan S, Sun X, Hatkar R, Box B, Nunes SS, Nostro MC (co-corresponding author). “Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models“. Cell Stem Cell. (2021)
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Sun X and Nunes SS (corresponding author). “Development and characterization of a type 2 diabetes model in immunocompromised rats for application in xenotransplantation studies”. bioRxiv. (2021)
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Aghazadeh Y, Khan S, Nkennor B and Nunes SS (corresponding author). Cell-based therapies for vascular regeneration: Past, present and future. Pharmacology & Therapeutics. (2021)
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Aghazadeh Y, Sarangi F, Poon F, Nkennor B, Nunes SS, Nostro MC. “GP2+ pancreatic progenitors generate functional beta cells and do not form teratoma in vivo”. (2021) BioRxiv. doi.org/10.1101/2021.05.15.444293
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Funakoshi S, Fernandes I, Mastikhina O, Wilkingson D, Tran T, Dhahri W, Mazine A, Yang D, Burnett B, Lee J, Protze S, Bader G, Nunes SS, Laflamme M and Keller G. “Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells”. Nature Communications. (2021) 12:3155.
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Williams KW, Liang T, Masse S, Khan S, Hatkar R, Keller G, Nanthakumar K and Nunes SS (corresponding author). “A 3-D human model of complex cardiac arrhythmias”. Acta Biomaterialia. (2021)
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Soon K, Mourad O, and Nunes SS (corresponding author). “Engineered cardiac microtissues: The state-of-the-(he)art”. Stem Cells. (2021). doi: 10.1002/stem.3376
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Sun X, Wu J, Qiang B, Romagnuolo R, Gagliardi M, Keller G, Laflamme M, Li RK and Nunes SS (corresponding author). “Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats". Science Translational Medicine. Sep 2020.
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Sun X, Nkennor R, Mastikhina O, Soon K and Nunes SS (corresponding author). “Endothelium-mediated contributions to fibrosis”. Seminars in Cell & Developmental Biology - Special issue on Mechanisms of Fibrosis. May 2020.
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Mastikhina O, Moon B-U, Williams K, Hatkar R, Gustafson D, Mourad O, Sun X, Koo M, Lam AYL, Sun Y, Fish JE, Young EKW, Nunes SS (corresponding author). “Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing“ Biomaterials. Mar 2020.
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Altalhi W, Hatkar R, Hoying JB, Aghazadeh Y and Nunes SS (corresponding author). “Type I diabetes delays perfusion and engraftment of 3D constructs by impinging on angiogenesis; which can be rescued by hepatocyte growth factor supplementation”. 2019 Young Innovators Special Issue of the Cellular and Molecular Bioengineering journal. May 2019.
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Mastikhina O, Moon B-U, Williams K, Hatkar R, Gustafson D, Sun X, Koo M, Lam AYL, Sun Y, Fish JE, Young EKW, Nunes SS (corresponding author). “Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening“ bioRxiv, 632406. May 2019.
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Sun X and Nunes SS (corresponding author). "Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation”. JoVE. May 2017. Issue 123.
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Sun X and Nunes SS (corresponding author). "Bioengineering Approaches to Mature Human Pluripotent Stem Cell-derived Cardiomyocytes”. Front Cell Dev Biol, Stem Cell Research section. Mar 2017. 5:19.
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Altalhi W, Sun X, Sivak JM, Husain M and Nunes SS (corresponding author). "Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner". Biomaterials. Mar 2017.
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Nunes SS (co-corresponding author), Feric N, Pahnke A, Miklas JW, Li M, Coles J, Gagliardi M, Keller G and Radisic M. “Human stem cell-derived cardiac model of chronic drug exposure”. ACS Biomaterials Science & Engineering. April 2016. 
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Zhang B, Montgomery M, Chamberlain D, Wells LA, Nunes SS, Nanthakumar K, Sefton MV and Radisic M. “AngioChip: a biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis”. Nature Materials. Mar 2016. 1-10.
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Sun X, Evren S and Nunes SS (corresponding author). “Blood vessel maturation in health and disease and its implications for vascularization of engineered tissues”. Critical Reviews in Biomedical Engineering. June 2016. 5-6(43):433-454.
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Sun, X and Nunes SS (corresponding author). “Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes”. Methods. May 2016. (101)21-26.
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Sun, X, Altalhi W and Nunes SS (corresponding author). “Vascularization strategies of engineered tissues and their application in cardiac regeneration”. Advanced Drug Delivery Reviews special issue: Tissue engineering of the heart: from in vitro models to regenerative solutions (Invited). Jan 2016. 96:183-194.
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Sun, X and Nunes SS (corresponding author). “Overview of hydrogel-based strategies for application in cardiac tissue regeneration”. Biomedical Materials. June 2015. 10 (3): 034005.
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Zhao Y. Feric N. Thanvadiran N. Nunes SS, Radisic M. “The role of tissue engineering and biomaterials in cardiac regenerative medicine”. Canadian Journal of Cardiology. Nov 2014. 30: 1307-1322.
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Miklas JW, Nunes SS, Sofla A and Radisic M. "Bioreactor for modulation of cardiac microtissue phenotype by combined mechanical and electrical stimulation”. Biofabrication. Special issue: Micro and nano materials for tissue engineering. 2014, 6(2):024113.
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Krishnan L, Chang CC, Nunes SS, Clayton L, Williams SK, Weiss JA and Hoying JB. “Manipulating the microvasculature and its microenvironment” Critical Reviews in Biomedical Engineering. Dec 2013. 2(41):91-123.

Nunes SS (corresponding author), Miklas JW and Radisic M. "Maturation of stem cell-derived human heart tissue by mimicking fetal heart rate”. Editorial, Future Cardiology. Nov 2013. 9(6):751-754.
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Nunes SS, Miklas JW, Liu J, Aschar-Sobi R, Xiao Y, Zhang B, Jiang J, Masse S, Gagliardi M, Hsieh A, Thanvadiran N, Laflamme MA, Nanthakumar K, Gross G, Backx P, Keller G and Radisic M. "Biowire: a platform for maturation of human pluripotent stem cell derived cardiomyocytes". Nature Methods. Aug 2013. 10:781-787.
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Miklas JW, Nunes SS, Radisic M. “Engineering cardiac tissues from pluripotent stem cells for drug screening and studies of cell maturation”. Invited review by the Israel Journal of Chemistry – New Biomaterials honoring the 2013 Wolf Prize to Robert Langer. Oct 2013. (53) 680-694.

Nunes SS, Maijub JG, Krishnan L, Ramakrishnan VM, Clayton LR, Williams SK, Hoying, JB and Boyd NL. "Generation of a functional liver tissue mimic using adipose stromal vascular fraction cell-derived vasculatures". Scientific Reports. Jul 2013. 3:2141.
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Thavandiran N, Nunes SS, Xiao Y and Radisic M. “Topological and electrical control of cardiac differentiation and assembly” Stem Cell Research & Therapy. Feb 2013. 14;4(1):14.
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Martin C, Sofla A, Zhang B, Nunes SS and Radisic M. "Fusible core molding for fabrication of branched three-dimensional perfusable microvessels for vascular tissue engineering". International Journal of Artificial Organs. 2013, 36(3):159-65.
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Boyd NL, Nunes SS, Krishnan L, Jokinen JD, Bugg AR and Hoying JB. "Dissecting the role of human embryonic stem cell derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in 3-dimensional environments". Tissue Engineering part A. 2013, 19(1-2):211-23.
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Chang CC, Krishnan L, Nunes SS, Church KH, Edgar, LT, Boland ED, Weiss JA, Williams SK, and Hoying JB. "Determinants of microvascular network topologies in implanted neovasculatures". Arteriosclerosis, Thrombosis and Vascular Biology. 2012. 32(1):5-14.
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Chiu LLY, Iyer RK, Reis LA, Nunes SS and Radisic M. "Cardiac tissue engineering: current state and perspectives". Frontiers in Bioscience. 2012. (17):1533-50.

Nunes SS (corresponding author), Rekapally HR, Chang CC and Hoying JB. “Vessel arterial-venous plasticity in adult neovascularization”. PLoS ONE. 2011. 6(11):e27332.
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Nunes SS (co-corresponding author), Song H, Chiang CK and Radisic M. "Stem cell-based cardiac tissue engineering". J. of Cardiovascular Translational Research, 2011. 4(5):592-602.
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Boyd NL, Nunes SS, Jokinen JD, Krishnan L, Chen Y, Smith KH, Stice SL, Hoying JB. “Microvascular mural cell functionality of human embryonic stem cell-derived mesenchymal cells”. Tissue Engineering part A. 2011, (17) 1537-1548.
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Alves TR, Fonseca AC, Nunes SS, Silva AO, Dubois L, Faria J, Kahn SA, Viana NB, Marcondes J, Legrand C, Moura Neto V, Morandi V. “Tenascin-C in the extracellular matrix promotes the selection of highly proliferative and tubulogenesis-defective endothelial cells”. Experimental Cell Research, 2011. 10;317 (15):2073-85.
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Nunes SS, Krishnan L, Gerard CS, Dale JR, Maddie MA, Benton RL, Hoying JB. “Angiogenic potential of microvessel fragments is independent of tissue of origin and can be influenced by the cellular composition of the implants”. Microcirculation. 2010, 17(7) 557-567.
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Nunes SS, Greer KA, Stiening CM, Chen HYS, Kidd KR, Schwartz MA, Sullivan CJ, Rekapally H, Hoying JB. “Implanted microvessels progress through distinct neovascularization phenotypes”.  Microvascular Research. 2010, 79(1): 10-20.
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Chang CC, Nunes SS, Sibole SC, Krishnan L, Williams SK, Hoying, JB. “Angiogenesis in a microvascular construct for transplantation depends on the method of chamber circulation”. Tissue Engineering Part A. 2010, 16(3): 795-805.
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Nunes SS, Outeiro-Bernstein MA, Juliano L, Vardiero F, Nader HB, Woods A, Legrand C, Morandi V. “Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1”. J Cell Physiology 2008, 214(3): 828-37.
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Outeiro-Bernstein MAF, Nunes SS, Andrade ACM, Alves TR, Legrand C, Morandi V. “A recombinant NH2-terminal heparin-binding domain of the adhesive glycoprotein thrombospondin-1, promotes endothelial tube formation and cell survival: a possible role for syndecan-4 proteoglycan”. Matrix Biology. 2002, 21: 311-324.
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Book chapter:

Miklas JW, Nunes SS, Zhang B and Radisic M. “Design and fabrication of biological wires” in Cardiac Tissue Engineering Methods and Protocols. Volume 1181. 2014, 157-165.

Mourad O, Nkennor B, Nunes SS. “Compounding effects of diabetes in vessel formation in microvessel fragment–based engineered constructs" in The Science, Etiology and Mechanobiology of Diabetes and its Complications.
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